Motif ID: FOS_FOS{B,L1}_JUN{B,D}.p2

Z-value: 4.960


Transcription factors associated with FOS_FOS{B,L1}_JUN{B,D}.p2:

Gene SymbolEntrez IDGene Name
FOS 2353 v-fos FBJ murine osteosarcoma viral oncogene homolog
FOSB 2354 FBJ murine osteosarcoma viral oncogene homolog B
FOSL1 8061 FOS-like antigen 1
JUNB 3726 jun B proto-oncogene
JUND 3727 jun D proto-oncogene



Activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2.

activity profile for motif FOS_FOS{B,L1}_JUN{B,D}.p2


Sorted Z-values histogram for motif FOS_FOS{B,L1}_JUN{B,D}.p2

Sorted Z-values for motif FOS_FOS{B,L1}_JUN{B,D}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of FOS_FOS{B,L1}_JUN{B,D}.p2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_19706979 30.112 NM_000227
NM_001127718
LAMA3

laminin, alpha 3

chr1_-_177378801 27.263 NM_001136000
NM_001168239
NM_005158
ABL2


v-abl Abelson murine leukemia viral oncogene homolog 2


chr1_+_181421984 23.796 LAMC2
laminin, gamma 2
chr3_-_152517204 21.413 NM_023915
GPR87
G protein-coupled receptor 87
chr12_+_13240868 17.604 NM_001423
EMP1
epithelial membrane protein 1
chr12_+_13240983 17.062 EMP1
epithelial membrane protein 1
chr12_+_13240987 17.010 EMP1
epithelial membrane protein 1
chr1_+_181422016 15.530 LAMC2
laminin, gamma 2
chr5_+_145297490 15.304 SH3RF2
SH3 domain containing ring finger 2
chr1_+_181421796 15.182 NM_005562
NM_018891
LAMC2

laminin, gamma 2

chr17_-_36996611 14.748 NM_000526
KRT14
keratin 14
chr1_+_221955876 13.957 NM_001146068
CAPN2
calpain 2, (m/II) large subunit
chr18_+_59593591 13.714 NM_003784
SERPINB7
serpin peptidase inhibitor, clade B (ovalbumin), member 7
chr1_-_207891264 13.601 NM_001017402
LAMB3
laminin, beta 3
chr3_+_11153778 13.296 NM_001098213
HRH1
histamine receptor H1
chr17_-_37022465 12.900 NM_005557
KRT16
keratin 16
chr6_+_47774247 12.816 NM_153838
GPR115
G protein-coupled receptor 115
chr11_+_101488380 12.663 NM_001195045
YAP1
Yes-associated protein 1
chr10_+_24795465 12.144 KIAA1217
KIAA1217
chr10_+_24795446 11.662 KIAA1217
KIAA1217
chr20_+_19903778 11.387 RIN2
Ras and Rab interactor 2
chr10_-_88720908 11.209 LOC100133190
hypothetical LOC100133190
chr12_-_51173238 11.133 NM_005554
KRT6A
keratin 6A
chr18_+_59295123 11.055 NM_002639
SERPINB5
serpin peptidase inhibitor, clade B (ovalbumin), member 5
chr20_-_17487480 10.655 NM_001161705
BFSP1
beaded filament structural protein 1, filensin
chr12_-_56445653 10.385 CYP27B1
cytochrome P450, family 27, subfamily B, polypeptide 1
chr15_+_38319326 10.369 NM_020168
PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr19_-_43955984 10.346 NM_002307
LGALS7
LGALS7B
lectin, galactoside-binding, soluble, 7
lectin, galactoside-binding, soluble, 7B
chr11_-_65860450 10.316 NM_004292
RIN1
Ras and Rab interactor 1
chr5_+_150000394 10.299 NM_001109974
NM_007286
SYNPO

synaptopodin

chr14_-_104507862 9.974 AHNAK2
AHNAK nucleoprotein 2
chr21_+_29439768 9.843 C21orf7
chromosome 21 open reading frame 7
chr13_+_77007809 9.671 NM_001160706
NM_003843
NM_144777
SCEL


sciellin


chr10_+_118177371 9.572 NM_001011709
PNLIPRP3
pancreatic lipase-related protein 3
chr1_+_34993234 9.453 NM_005268
GJB5
gap junction protein, beta 5, 31.1kDa
chr6_-_152744143 9.410 SYNE1
spectrin repeat containing, nuclear envelope 1
chr8_+_22900863 9.269 NM_001160036
RHOBTB2
Rho-related BTB domain containing 2
chr7_+_116099648 9.244 NM_000245
NM_001127500
MET

met proto-oncogene (hepatocyte growth factor receptor)

chr6_+_41712907 8.921 MDFI
MyoD family inhibitor
chr2_+_166034402 8.697 NM_001172173
CSRNP3
cysteine-serine-rich nuclear protein 3
chr6_-_152744022 8.647 SYNE1
spectrin repeat containing, nuclear envelope 1
chr15_-_38417564 8.433 C15orf52
chromosome 15 open reading frame 52
chr11_-_117640166 8.412 MPZL2
myelin protein zero-like 2
chr3_-_150578103 8.390 TM4SF1
transmembrane 4 L six family member 1
chr3_-_48607596 8.381 NM_000094
COL7A1
collagen, type VII, alpha 1
chr1_-_94779727 8.369 NM_001178096
NM_001993
F3

coagulation factor III (thromboplastin, tissue factor)

chr6_+_31190505 8.323 NM_014068
PSORS1C1
psoriasis susceptibility 1 candidate 1
chr15_-_53996597 8.123 NM_198400
NEDD4
neural precursor cell expressed, developmentally down-regulated 4
chr19_+_43486640 8.100 NM_033520
C19orf33
chromosome 19 open reading frame 33
chr17_-_7434113 7.951 NM_006942
SOX15
SRY (sex determining region Y)-box 15
chr4_-_115120251 7.904 NM_024590
ARSJ
arylsulfatase family, member J
chr11_-_117640078 7.880


chr14_+_51025604 7.845 NM_001042481
FRMD6
FERM domain containing 6
chr1_-_115682374 7.837 NM_002506
NGF
nerve growth factor (beta polypeptide)
chr3_-_150578207 7.759 NM_014220
TM4SF1
transmembrane 4 L six family member 1
chr3_-_150578148 7.727 TM4SF1
transmembrane 4 L six family member 1
chr1_+_151270301 7.692 NM_003125
SPRR1B
small proline-rich protein 1B
chr9_-_129381086 7.641 NM_001035534
FAM129B
family with sequence similarity 129, member B
chr17_-_37034288 7.581 NM_000422
KRT17
keratin 17
chr1_-_205272619 7.538 NM_001083924
NM_023938
C1orf116

chromosome 1 open reading frame 116

chr3_-_150578023 7.338 TM4SF1
transmembrane 4 L six family member 1
chr20_-_35586366 7.324 NM_001167823
BLCAP
bladder cancer associated protein
chr1_-_108032645 7.260 NM_001079874
VAV3
vav 3 guanine nucleotide exchange factor
chr17_-_24068759 7.102 NM_001144942
NM_031934
RAB34

RAB34, member RAS oncogene family

chr2_-_65447267 7.024 SPRED2
sprouty-related, EVH1 domain containing 2
chr11_-_117640196 6.949 MPZL2
myelin protein zero-like 2
chr4_+_183302105 6.846 ODZ3
odz, odd Oz/ten-m homolog 3 (Drosophila)
chr19_-_52427698 6.836 NM_001127240
NM_001127241
NM_001127242
BBC3


BCL2 binding component 3


chr1_+_81544432 6.811 LPHN2
latrophilin 2
chr9_+_676640 6.809


chrX_-_33139349 6.766 NM_004006
DMD
dystrophin
chr11_+_384238 6.697 PKP3
plakophilin 3
chrX_-_19598912 6.679 NM_001184960
SH3KBP1
SH3-domain kinase binding protein 1
chr3_+_64645819 6.604 LOC100507098
hypothetical LOC100507098
chr18_+_54039818 6.539 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr2_-_65447370 6.509 NM_001128210
SPRED2
sprouty-related, EVH1 domain containing 2
chr11_-_6298284 6.460 NM_145040
PRKCDBP
protein kinase C, delta binding protein
chr19_-_56215084 6.426 NM_002776
NM_001077500
KLK10

kallikrein-related peptidase 10

chr9_-_90456824 6.360 NM_001100111
LOC286238
hypothetical protein LOC286238
chr16_-_2848106 6.336 NM_022119
PRSS22
protease, serine, 22
chr5_+_147562531 6.240 NM_001195290
NM_205841
SPINK6

serine peptidase inhibitor, Kazal type 6

chr11_+_384199 6.213 NM_007183
PKP3
plakophilin 3
chr9_-_116920232 6.207 NM_002160
TNC
tenascin C
chr11_-_117640407 6.147 NM_005797
NM_144765
MPZL2

myelin protein zero-like 2

chr6_-_10527772 6.099 NM_001042425
TFAP2A
transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
chr18_+_59705918 6.077 NM_001143818
NM_002575
SERPINB2

serpin peptidase inhibitor, clade B (ovalbumin), member 2

chr1_+_17719405 6.070 ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr4_+_120276386 6.043 NM_016599
MYOZ2
myozenin 2
chr11_-_128399218 6.010 NM_014715
ARHGAP32
Rho GTPase activating protein 32
chr7_+_28692122 5.954 NM_001011666
CREB5
cAMP responsive element binding protein 5
chr13_-_85271329 5.933 NM_032229
SLITRK6
SLIT and NTRK-like family, member 6
chr2_+_113591940 5.769 NM_000577
NM_173841
NM_173843
IL1RN


interleukin 1 receptor antagonist


chr18_+_50646616 5.767 NM_004163
RAB27B
RAB27B, member RAS oncogene family
chr5_+_36644187 5.671 NM_001166695
SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr8_+_120289735 5.616 NM_052886
MAL2
mal, T-cell differentiation protein 2 (gene/pseudogene)
chr19_+_43971689 5.608 NM_001042507
LGALS7B
lectin, galactoside-binding, soluble, 7B
chr1_+_185064654 5.593 NM_024420
PLA2G4A
phospholipase A2, group IVA (cytosolic, calcium-dependent)
chr18_+_54039779 5.586 NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr1_+_27062215 5.570 NM_006142
SFN
stratifin
chr6_+_121798443 5.563 NM_000165
GJA1
gap junction protein, alpha 1, 43kDa
chr11_+_20005704 5.545 NAV2
neuron navigator 2
chr2_-_166359016 5.499 NM_004482
GALNT3
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)
chr6_+_74462654 5.483 CD109
CD109 molecule
chr1_-_28392966 5.440 NM_001164722
NM_001164721
PTAFR

platelet-activating factor receptor

chr18_+_54039730 5.421 NM_001144966
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like
chr11_+_101423378 5.382 NM_001195005
NM_032930
C11orf70

chromosome 11 open reading frame 70

chr11_+_696607 5.358 EPS8L2
EPS8-like 2
chr6_-_169392771 5.349


chr5_+_145296313 5.328 NM_152550
SH3RF2
SH3 domain containing ring finger 2
chr12_-_68369322 5.243 NM_152439
BEST3
bestrophin 3
chr6_+_83129641 5.200 NM_006670
TPBG
trophoblast glycoprotein
chr13_-_35327798 5.095 NM_001195415
NM_001195416
NM_001195430
DCLK1


doublecortin-like kinase 1


chr5_-_1935764 5.040 NM_016358
IRX4
iroquois homeobox 4
chr5_+_35892747 5.028 NM_002185
IL7R
interleukin 7 receptor
chr4_+_108965167 4.990 NM_001136258
SGMS2
sphingomyelin synthase 2
chr9_+_102231616 4.946 NM_001198806
C9orf30
chromosome 9 open reading frame 30
chr2_+_36777336 4.863 NM_001177969
NM_001177970
NM_001177971
NM_001177972
NM_053276
VIT




vitrin




chr7_-_42243142 4.811 NM_000168
GLI3
GLI family zinc finger 3
chr17_+_71229151 4.809 ITGB4
integrin, beta 4
chr4_+_81325447 4.788 NM_020226
PRDM8
PR domain containing 8
chr6_+_154449334 4.763 NM_001145287
OPRM1
opioid receptor, mu 1
chr9_+_5500544 4.758 NM_025239
PDCD1LG2
programmed cell death 1 ligand 2
chr3_-_11585264 4.742 NM_001128221
VGLL4
vestigial like 4 (Drosophila)
chr2_+_219180862 4.735 PLCD4
phospholipase C, delta 4
chr17_+_71229191 4.719 ITGB4
integrin, beta 4
chrX_+_99785818 4.684 NM_014467
SRPX2
sushi-repeat containing protein, X-linked 2
chr3_+_30623376 4.632 TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr13_-_37070862 4.617 NM_001135934
NM_001135935
NM_001135936
NM_006475
POSTN



periostin, osteoblast specific factor



chr3_+_57069508 4.614 NM_181727
SPATA12
spermatogenesis associated 12
chr16_+_56219802 4.586 NM_001145771
NM_001145772
NM_001145773
NM_201524
NM_201525
GPR56




G protein-coupled receptor 56




chr20_+_33223434 4.577 NM_006404
PROCR
protein C receptor, endothelial
chr17_+_71229110 4.530 NM_000213
NM_001005731
ITGB4

integrin, beta 4

chr1_+_34997928 4.528 NM_153212
GJB4
gap junction protein, beta 4, 30.3kDa
chr3_-_31997738 4.494 OSBPL10
oxysterol binding protein-like 10
chr17_-_36928604 4.484 NM_002275
KRT15
keratin 15
chr12_-_51912101 4.472 NM_000966
RARG
retinoic acid receptor, gamma
chr15_+_38849450 4.445 NM_001130448
C15orf62
chromosome 15 open reading frame 62
chr7_-_104696678 4.411 NM_182691
SRPK2
SRSF protein kinase 2
chr8_-_38505331 4.379 NM_207412
C8orf86
chromosome 8 open reading frame 86
chr19_-_48661563 4.327 NM_014400
LYPD3
LY6/PLAUR domain containing 3
chr1_-_36589744 4.324


chr18_-_72336133 4.304 NM_014643
ZNF516
zinc finger protein 516
chr3_-_188936941 4.279 NM_001130845
BCL6
B-cell CLL/lymphoma 6
chr5_+_36642424 4.209 SLC1A3
solute carrier family 1 (glial high affinity glutamate transporter), member 3
chr15_+_38318528 4.160 PAK6
p21 protein (Cdc42/Rac)-activated kinase 6
chr1_+_44171578 4.111 NM_001136215
NM_057090
NM_057091
ARTN


artemin


chr1_+_28637247 4.105 NM_023923
PHACTR4
phosphatase and actin regulator 4
chr16_+_70117523 4.077 NM_005769
NM_001166395
CHST4

carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4

chr4_+_35959638 4.073 NM_001136536
DTHD1
death domain containing 1
chr1_-_117554999 4.023 NM_024626
VTCN1
V-set domain containing T cell activation inhibitor 1
chr5_+_59819761 4.022 PART1
prostate androgen-regulated transcript 1 (non-protein coding)
chr5_+_73145098 4.019 RGNEF
190 kDa guanine nucleotide exchange factor
chr19_-_60573552 4.009 NM_000641
IL11
interleukin 11
chr10_-_62002672 4.006 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr3_-_87122936 4.000 NM_016206
VGLL3
vestigial like 3 (Drosophila)
chr5_-_54317102 3.968 NM_001135604
NM_007036
ESM1

endothelial cell-specific molecule 1

chr1_+_35019376 3.963 NM_024009
GJB3
gap junction protein, beta 3, 31kDa
chrX_+_99786044 3.961 SRPX2
sushi-repeat containing protein, X-linked 2
chr6_+_74462485 3.925 CD109
CD109 molecule
chr1_-_221920023 3.899 NM_001143962
CAPN8
calpain 8
chr1_-_89261021 3.893 NM_018284
GBP3
guanylate binding protein 3
chr2_-_73170290 3.891 RAB11FIP5
RAB11 family interacting protein 5 (class I)
chr7_-_16811131 3.877 NM_006408
AGR2
anterior gradient homolog 2 (Xenopus laevis)
chr4_-_122304925 3.869 NM_024873
TNIP3
TNFAIP3 interacting protein 3
chr3_+_190147633 3.825 TPRG1
tumor protein p63 regulated 1
chr17_-_24069299 3.818 NM_001142624
NM_001142625
NM_001144943
RAB34


RAB34, member RAS oncogene family


chr10_+_123862430 3.809 TACC2
transforming, acidic coiled-coil containing protein 2
chr19_-_18912112 3.806 NM_001145722
NM_001145721
HOMER3

homer homolog 3 (Drosophila)

chr1_-_151804929 3.782 NM_005978
S100A2
S100 calcium binding protein A2
chr11_-_102331643 3.772 NM_002427
MMP13
matrix metallopeptidase 13 (collagenase 3)
chr4_-_35922288 3.771 NM_015230
ARAP2
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr7_-_42243318 3.765 GLI3
GLI family zinc finger 3
chr6_-_138470160 3.746 NM_022121
PERP
PERP, TP53 apoptosis effector
chr15_-_58477407 3.744 NM_001002857
NM_001002858
NM_001136015
NM_004039
ANXA2



annexin A2



chr1_+_24518501 3.731 NM_001195010
GRHL3
grainyhead-like 3 (Drosophila)
chr6_-_116799548 3.688 LOC100287467
hypothetical LOC100287467
chr14_+_95792299 3.681 NM_000710
BDKRB1
bradykinin receptor B1
chr4_+_169989680 3.674 NM_001166110
PALLD
palladin, cytoskeletal associated protein
chr1_+_24518398 3.608 NM_198173
NM_198174
GRHL3

grainyhead-like 3 (Drosophila)

chr18_-_45630154 3.603 MYO5B
myosin VB
chr14_+_20537253 3.590 NM_014579
SLC39A2
solute carrier family 39 (zinc transporter), member 2
chr2_-_165406098 3.586 COBLL1
COBL-like 1
chr3_+_30622905 3.538 NM_001024847
NM_003242
TGFBR2

transforming growth factor, beta receptor II (70/80kDa)

chr12_+_106498763 3.522 NM_001017523
BTBD11
BTB (POZ) domain containing 11
chr6_+_12398514 3.499 NM_001168319
NM_001955
EDN1

endothelin 1

chr19_+_7859380 3.485 NM_025061
LRRC8E
leucine rich repeat containing 8 family, member E
chr4_-_74307637 3.484 ANKRD17
ankyrin repeat domain 17
chr5_-_134942346 3.483 CXCL14
chemokine (C-X-C motif) ligand 14
chr1_+_150753601 3.465 NM_019060
CRCT1
cysteine-rich C-terminal 1
chr6_+_74462630 3.445 CD109
CD109 molecule
chr2_-_142605010 3.399 LRP1B
low density lipoprotein receptor-related protein 1B
chr10_-_118022965 3.394 NM_005264
GFRA1
GDNF family receptor alpha 1
chr14_+_104218487 3.378


chr3_+_185520744 3.362 NM_004953
EIF4G1
eukaryotic translation initiation factor 4 gamma, 1
chr3_+_31998269 3.360 NM_001137674
ZNF860
zinc finger protein 860
chr3_+_161877640 3.351 NM_025047
ARL14
ADP-ribosylation factor-like 14
chr22_-_43986896 3.331 KIAA0930
KIAA0930
chr1_+_199130571 3.330 NM_001142569
C1orf106
chromosome 1 open reading frame 106
chr12_-_102967828 3.293 GLT8D2
glycosyltransferase 8 domain containing 2
chr4_+_74825138 3.283 NM_000584
IL8
interleukin 8

Gene Ontology Analysis

Gene overrepresentation in process category:

enrichment   p-value GO term description
6.83 1.07e-03 GO:0045103 intermediate filament-based process
1.31 1.95e-03 GO:0048856 anatomical structure development
7.23 2.22e-03 GO:0045104 intermediate filament cytoskeleton organization
1.57 3.15e-03 GO:0051246 regulation of protein metabolic process
1.31 6.14e-03 GO:0048731 system development
1.61 6.26e-03 GO:0009611 response to wounding
8.69 7.47e-03 GO:0031581 hemidesmosome assembly
2.37 7.75e-03 GO:0008544 epidermis development
1.62 7.82e-03 GO:0009888 tissue development
1.27 1.03e-02 GO:0007165 signal transduction
1.47 1.30e-02 GO:0035556 intracellular signal transduction
3.58 1.45e-02 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
3.58 1.45e-02 GO:0072395 signal transduction involved in cell cycle checkpoint
3.58 1.45e-02 GO:0072401 signal transduction involved in DNA integrity checkpoint
3.58 1.45e-02 GO:0072404 signal transduction involved in G1/S transition checkpoint
3.58 1.45e-02 GO:0072413 signal transduction involved in mitotic cell cycle checkpoint
3.58 1.45e-02 GO:0072422 signal transduction involved in DNA damage checkpoint
3.58 1.45e-02 GO:0072431 signal transduction involved in mitotic cell cycle G1/S transition DNA damage checkpoint
3.58 1.45e-02 GO:0072474 signal transduction involved in mitotic cell cycle G1/S checkpoint
1.54 2.72e-02 GO:0042127 regulation of cell proliferation
3.41 2.83e-02 GO:0071158 positive regulation of cell cycle arrest
1.84 4.19e-02 GO:0043086 negative regulation of catalytic activity
1.56 4.22e-02 GO:0016265 death
1.24 4.79e-02 GO:0032502 developmental process

Gene overrepresentation in compartment category:

enrichment   p-value GO term description
3.68 7.07e-04 GO:0000502 proteasome complex
1.43 1.18e-03 GO:0005856 cytoskeleton
3.78 8.56e-03 GO:0031093 platelet alpha granule lumen
3.70 1.10e-02 GO:0034774 secretory granule lumen
1.21 1.32e-02 GO:0071944 cell periphery
1.21 1.57e-02 GO:0005886 plasma membrane
3.55 1.76e-02 GO:0060205 cytoplasmic membrane-bounded vesicle lumen
5.20 2.69e-02 GO:0001533 cornified envelope
3.41 2.74e-02 GO:0031983 vesicle lumen
1.30 3.42e-02 GO:0005576 extracellular region
1.44 3.93e-02 GO:0044421 extracellular region part
1.84 4.63e-02 GO:0005578 proteinaceous extracellular matrix

Gene overrepresentation in function category:

enrichment   p-value GO term description
2.95 1.01e-02 GO:0004867 serine-type endopeptidase inhibitor activity
2.38 1.33e-02 GO:0030414 peptidase inhibitor activity
2.42 1.42e-02 GO:0004866 endopeptidase inhibitor activity
2.32 2.90e-02 GO:0061135 endopeptidase regulator activity
1.13 4.43e-02 GO:0005515 protein binding